A postdoctoral position is available in the Department of Biomedicine at the University of Basel to join the Developmental Genetics Group led by Prof. Rolf Zeller and PD Dr. Aimée Zuniga.
Postdoctoral Position - Genetic and Epigenetic Control of Mouse Organ Development
Your position Integration of signaling inputs into transcriptional regulation is central to controlling the expansion, specification and differentiation of progenitor and stem cells during tissue and organ development in vertebrate embryos. Understanding the epigenetic and regulatory mechanisms underlying signaling systems and gene networks forms the core of our research interests. The PhD project will take advantage of CRISPR/Cas9-mediated genome editing in combination with epigenetic, chromatin and transcriptome analyses in mouse embryos. We mostly study the developing mouse limb as a paradigm to understand the molecular mechanisms regulating expansion, specification and initiation of chondrogenic differentiation of limb bud mesenchymal progenitors. In parallel, we are studying the functionally relevant molecular changes that underlie the vast evolutionary diversification of the vertebrate limb skeleton. There are several possible projects within the framework of our ERC and SNF funded research that will be discussed with the applicants. Please note that this research requires using animals and embryos (mostly mice). Relevant publications on the topics include: Bénazet et al. 2009, Science 323, 1050-1053; Lopez-Rios et al. 2014, Nature 511, 46-51, Osterwalder et al. 2014, Dev Cell 31, 345–357; Laurent et al. 2017, Cell Reports 19, 1602-1613 - for a recent review see: Zuniga 2015, Development 142, 3810-3820.
Your profile We are looking for highly motivated postdoctoral fellows who are in progress of completing or have recently completed their PhD in one of the following fields: Molecular Developmental (or Evo-Devo) Biology, Systems Biology and/or Chromatin/Transcriptional Regulation. Applicants require minimally one first author publication in a top journal in one of these fields and have completed their PhD maximally 12 months ago at the time of applying. Applications not full-filling these criteria will not be considered any further. Successful applicants will be asked and assisted to apply for their own fellowship to cover their living expenses for the first 12-24 months of their postdoctoral stay in the group.
We offer you The successful applicant will join an international research team in a biomedical research environment. In addition to your own project, you will have the chance to participate in supervision of graduate students and be mentored to develop your own scientific leadership skills.
For further inquiries contact Rolf Zeller (email@example.com) or Aimée Zuniga (firstname.lastname@example.org).
Applicants should send a motivation letter, CV with complete publication list, grades for masters, summary of the PhD thesis and the names and addresses of three referees as one single PDF file to email@example.com and firstname.lastname@example.org (cc: email@example.com).
Please apply now – interviews will continue until the position is filled.