At Roche, we believe it's urgent to deliver medical solutions right now - even as we develop innovations for the future. We are passionate about transforming patients' lives and we are ambitious in both decision and action. And we believe that good business means a better world. That is why we come to work every single day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.
Within Roche's Pharma Research and Early Development (pRED), Neuroscience & Rare Diseases represents a major focus area where we are committed to realizing our long-term vision of changing lives of patients with severe brain disorders. Our research and early development activities center around large and rare indications within the four major pillars of neurodevelopmental disorders, movement disorders, dementias, and multiple sclerosis. With strengths across diverse disciplines, Roche is uniquely positioned to lead in transforming science to medicines for patients with disorders of the nervous system.
To achieve our goals, Roche pRED Neuroscience & Rare Diseases is currently undergoing a major recruitment effort for a large number of new positions to develop an effective discovery engine to develop the next generation of transformative therapies. Among these we are seeking a Discovery Scientist in Neurotransmitter Systems in Systems Neuroscience Section within the Department of Research. All positions are based in Basel, Switzerland.
We are seeking an independent and creative scientist interested in using their unique experience to drive exploratory research and drug discovery efforts for neurological and rare disease projects, with a focus on electrophysiology and systems neuroscience. In a highly cross-functional and collaborative environment, you will have the opportunity to contribute to the expansion of our drug discovery efforts in the area of neurodegenerative and neurodevelopmental diseases, sleep physiology, cellular and network communication, translational circuit readouts, and neuropharmacology.
As a Discovery Scientist in Neurotransmitter Systems, your main responsibilities are:
Provide electrophysiology and pharmacology support to drug discovery projects
Develop assays for drug screening based on recombinant receptors expressed in eukaryotic cells and Xenopus oocytes using manual patch clamp and two electrodes voltage-clamp
Analyze and interpret experimental data
Study brain circuits involved in Neurodevelopment Diseases using ex-vivo electrophysiological models
Take on the role of drug discovery project leader
Supervision of interns, associates and postdocs
In addition, you will:
Who you are:
You are someone who is deeply driven to change the lives of patients in need, with a desire to bring your unique experience to develop novel medicines, and influence your own career development.
Ph.D. with significant postdoctoral experience and a strong publication record in the neuroscience space
A deep knowledge in electrophysiology, ion channel biophysics, and pharmacology with hands-on experience including patch-clamp electrophysiology is required
Experience in scientific research of ex-vivo rodent animal models
You are a strong team player, and you foster a collaborative spirit with scientists and colleagues. You can adapt to a fast-paced, changing environment, are fluent in English, and have good presentation and communication skills
You're someone who wants to influence your own development. You're looking for a company where you have the opportunity to pursue your interests across functions and geographies
Cell culture and molecular biology knowledge
Experience in calcium imaging and/or optogenetics
Knowledge of programming languages (MATLAB, Python, C/C++)
Are you ready to apply? Roche embraces diversity and equal opportunity in a serious way. We are committed to building teams that represent a range of backgrounds, perspectives, and skills.
If you still have questions then please check our FAQs and videos on careers.roche.ch/faq.
Roche is an equal opportunity employer.
Research & Development, Research & Development > Research