At Roche, we believe it is urgent to deliver medical solutions now - even as we develop innovations for the future. We are passionate about improving the lives of patients with brain diseases, and strive for ambitious ideas, innovative approaches and urgent action. Our belief is that our success as a company will come from developing therapies for patients in need, which is why we come to work every single day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.
Within Roche's Pharma Research and Early Development (pRED), Neuroscience & Rare Diseases represents a major focus area where we are committed to realizing our long-term vision of changing lives of patients with severe brain disorders. Our preclinical research and early clinical development activities center around large and rare indications within the four major pillars of neurodevelopmental disorders, movement disorders, dementias, and multiple sclerosis. With unparalleled strengths across diverse disciplines, Roche is uniquely positioned to lead in transforming science to medicines for patients with disorders of the nervous system.
To achieve our goals, Roche pRED Neuroscience & Rare Diseases is currently undergoing a major and exciting recruitment effort for a large number of new positions to further build our discovery engine for the next generation of transformative therapies. Among these we are seeking a Discovery Scientist in the Section of Neuroimmunology within the Department of Neuroscience & Rare Diseases Research. All positions are based in Basel, Switzerland.
We employ state of the art biochemistry, cell- and molecular biology technologies to understand the complex target mechanisms in neuroimmunology and neuroinflammation. The position is in the Neuroimmunology Section, but the scientist will collaborate across pRED and engage with leading academic groups in the US and Europe. The applicant will have the opportunity to develop projects across the drug development value chain from target assessment to late stage clinical development, and to initiate projects in diverse disorders of the brain even beyond Phase 1 enabling studies.
We are looking for a Discovery Scientist with expertise in innate/adaptive immunology and proven experience in pursuing scientific investigation of neuroimmune interactions in CNS (patho) physiology. The individual will be part of the Neuroimmunology section and the Neuroinflammation laboratory, with the mission to bring novel therapeutics addressing neuroimmune dysregulation in diseases including multiple sclerosis, degenerative dementias and movement disorders, and neurodevelopmental disorders.
Your key responsibilities are:
Oversight of in-vitro and in-vivo neuroinflammatory models, aiding in drug discovery efforts from target assessment through lead optimization.
Contribute to the neuroimmune portfolio by identifying new targets and biomarkers for neuroinflammatory CNS disorders working in collaboration with neurogenomicists.
Support projects, identify and validate novel drug targets, contribute to our drug discovery strategy in neuroimmunology/neuroinflammation.
Publish your work in peer-review journals.
Opportunity to take on a the role of Research Project Leader (RPL), leading multidisciplinary drug discovery teams.
Supervision of interns, associates and postdoctoral fellows.
Who you are:
You hold a PhD in Neuroscience, Immunology or interdisciplinary biology with several years of drug discovery experience with interest in neuroscience and rare diseases. Research experience in immunology and/or neuroimmunology is required.
Drug discovery experience in studying immunity in the CNS (innate immune cells of the CNS and infiltrating immune cells) and/or studying immune cells at the borders of the brain is highly preferred.
Further preferred qualifications:
Proficient in neuroimmunology assay systems, with both cell-based and in vivo models. You must be comfortable working in the laboratory and should be proficient with flow cytometry and immune cell sorting from peripheral and brain tissues.
Experience in probing glia cell activation (transcriptomics to proteomics) and blood brain barrier integrity in models of neuroinflammation is highly preferred.
Prior laboratory experience in models of Multiple Sclerosis, Alzheimer's or Parkinson's disease strongly preferred.
Prior experience with imaging-related techniques like immunofluorescent labeling of cells and tissues and use of confocal microscopy.
Proven drug discovery productivity.
Excellent team player and driven by collaborative spirit and a drive to make medicines that better the lives of patients suffering from devastating neurologic disorders.
Are you ready to apply? Roche embraces diversity and equal opportunity in a serious way. We are committed to building teams that represent a range of backgrounds, perspectives, and skills.
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Research & Development, Research & Development > Research